Recommended dosing for lower limb spasticity: 10 Units/kg to 15 Units/kg per limb.The maximum recommended total dose administered per treatment session must not exceed 16 Units/kg or 640 Units, whichever is lower. Recommended dosing for upper limb spasticity: 8 Units/kg to 16 Units/kg per limb.Select dose based on the affected muscle, severity of spasticity, and treatment and adverse reaction history with all botulinum toxins.Re-treatment, based on return of clinical symptoms, should not occur in intervals of less than 12 weeks.The maximum recommended total dose per treatment session (upper and lower limb combined) in adults is 1500 Units.Dosing for lower limb spasticity: up to 1500 Units.Dosing for upper limb spasticity: between 500 Units and 1000 Units.Select dose based on muscles affected, severity of spasticity, and treatment and adverse reaction history with botulinum toxins.Re-treatment should be administered no more frequently than every 3 months.Administer a total dose of 50 Units, divided in five equal aliquots of 10 Units each, intramuscularly to affected muscles to achieve clinical effect.Titrate in 250 Unit steps according to patient's response.Re-treatment should not occur in intervals of less than 12 weeks.Re-treatment every 12 to 16 weeks or longer, as necessary, based on return of clinical symptoms with doses administered between 250 Units and 1000 Units to optimize clinical benefit.Initial dose is 500 Units given intramuscularly as a divided dose among the affected muscles.After reconstitution, DYSPORT should be used for only one injection session and for only one patient Reconstituted DYSPORT is intended for intramuscular injection only.Reconstitution instructions are specific for the 300 Unit and 500 Unit vials.Once reconstituted, store in original container in a refrigerator at 2☌ to 8☌ (36☏ to 46☏) and use within 24 hours.Preparation of DYSPORT Solution for Administration ( 2.2)
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